Allele/Variant

Egr4tm1Jmi

Species
Mus musculus
Symbol
Egr4tm1Jmi
Category
allele
Allele of gene
Egr4
Transgenic Constructs
None
Synonyms
None
Description
The insertion of a neomycin selection cassette deleted a portion of the zinc finger binding domain and precluded the translation of downstream amino acids. While normal transcript was undetected by Northern blot analysis of homozygous mutant brain and testis tissue, low levels of a transcript encoding 5' amino acids and a portion of neo was observed.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal male meiosis
MGI
abnormal seminiferous tubule epithelium morphology
MGI
abnormal seminiferous tubule morphology
MGI
abnormal sperm flagellum morphology
MGI
abnormal sperm head morphology
MGI
abnormal spermatogenesis
MGI
coiled sperm flagellum
MGI
decreased male germ cell number
MGI
decreased testis weight
MGI
detached sperm flagellum
MGI
Showing 1 - 10 of 18 rows
per page

Disease Associations

No data available