Allele/Variant

Tph1tm1Bdr

Species
Mus musculus
Symbol
Tph1tm1Bdr
Category
allele
Allele of gene
Tph1
Transgenic Constructs
None
Synonyms
  • Tph-
  • Tph1-
Description
An isoform specific disruption of the endogenous allele was achieved by the insertion of neomycin and thymidine kinase cassettes via homologous recombination. The disruption putatively resulted in functional ablation in the peripheral tissues. The endogenous allele encodes the rate-limiting enzyme for serotonin synthesis, and while serotonin was detected at normal levels in the brain, it was absent in the periphery, with the exception of low levels (4% of wild-type) detected in the duodenum.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

No data available

Disease Associations

No data available