Tph1^tm1Bdr

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Species

Mus musculus

Symbol

Tph1^tm1Bdr

Category

allele

Allele of gene

Tph1

Transgenic Constructs

None

Synonyms

• Tph^-
• Tph1^-

Description

An isoform specific disruption of the endogenous allele was achieved by the insertion of neomycin and thymidine kinase cassettes via homologous recombination. The disruption putatively resulted in functional ablation in the peripheral tissues. The endogenous allele encodes the rate-limiting enzyme for serotonin synthesis, and while serotonin was detected at normal levels in the brain, it was absent in the periphery, with the exception of low levels (4% of wild-type) detected in the duodenum.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations