Atp1a1^tm1Ling

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Species

Mus musculus

Symbol

Atp1a1^tm1Ling

Category

allele

Allele of gene

Atp1a1

Transgenic Constructs

None

Synonyms

• alpha1^-

Description

Exons 15 through 18 were replaced with an hprt cassette via homologous recombination. Both alpha 1 transcript and protein levels were reduced by ~40% in heterozygous mutant hearts. An aberrant alpha 1 transcript was detected but was not expected to produce a functional protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations