Atp1a2^tm2Ling

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Species

Mus musculus

Symbol

Atp1a2^tm2Ling

Category

allele

Allele of gene

Atp1a2

Transgenic Constructs

None

Synonyms

• alpha2^-

Description

The insertion of an hprt cassette into exon 4 resulted in an alpha 2 isoform specific disruption. Both alpha 2 transcript and protein levels were reduced by ~50% in heterozygous mutant hearts. An aberrant alpha 2 transcript was detected but was not expected to produce a functional protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations