Bsn^tm1Gund

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Species

Mus musculus

Symbol

Bsn^tm1Gund

Category

allele

Allele of gene

Bsn

Transgenic Constructs

None

Synonyms

• Bsn^-
• Bsn^DeltaEX4/5

Description

A portion of exon 4 and all of exon 5 were replaced with a lacZ-neo cassette inserted by homologous recombination. Northern blot and RT-PCR analysis identified two transcripts produced by the mutant allele. A shorter transcript encoded a protein in which the amino terminal of the endogenous protein was adjoined to lacZ. A longer transcript was the result of the aberrant splicing of exons 3 and 6. Protein produced from the longer transcript was detected by Western blot analysis and lacked a central region that included the carboxy terminal half of the second zinc finger (aa 505 to 2889).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations