Allele/Variant

Brca2tm1Hst

Species
Mus musculus
Symbol
Brca2tm1Hst
Category
allele
Allele of gene
Brca2
Transgenic Constructs
None
Synonyms
  • brca2lex1
Description
A hypomorphic allele was generated by the replacement of exon 27 (coding nt 9418 through 9984) with an HPRT minigene. RT-PCR analysis identified a transcript lacking the targeted sequence encoding the RAD51-interacting domain. Truncated protein is translated and the ability of the protein to bind RAD51 is retained, putatively via the BRC motifs encoded by exon 11. The mutant protein contains more than 94% of the wild-type amino acid sequence.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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