Allele/Variant

Mefvtm1Chae

Species
Mus musculus
Symbol
Mefvtm1Chae
Category
allele
Allele of gene
Mefv
Transgenic Constructs
None
Synonyms
None
Description
Homologous recombination of a targeting vector containing EGFP and neo replaced a 3' portion of exon 3. The disruption was designed to leave the PYRIN domain intact, similar to mutations identified in patients with famial mediterrean fever. Western blot analysis of peritoneal macrophages obtained from homozygous mutant mice identified a truncated protein containing GFP.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations