Allele/Variant

Tg(Plp1-cre/ERT2)1Ueli

Species
Mus musculus
Symbol
Tg(Plp1-cre/ERT2)1Ueli
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • PLP-CreERT2
  • PLP/Cre-ERT2
Description
The transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodendrocytes and Schwann cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations