Allele/Variant

Prkcqtm1.1Bai

Species
Mus musculus
Symbol
Prkcqtm1.1Bai
Category
allele
Allele of gene
Prkcq
Transgenic Constructs
None
Synonyms
  • PKCTheta-
  • PKCThetaDelta
Description
The floxed region encompassing about 10 kb of sequence, including a neo cassette and exons 3 and 4, was excised via cre mediated recombination in the germline. The deletion eliminated sequence encoding amino acids 10 through 87 and resulted in a frameshift mutation after codon 9. Western blot analysis indicated an absence of protein in thymocytes and CD3+ T cells. Sequence and splice sites corresponding to the testis-expressed isoform were left intact.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations