Prkcq^tm1.1Bai

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Species

Mus musculus

Symbol

Prkcq^tm1.1Bai

Category

allele

Allele of gene

Prkcq

Transgenic Constructs

None

Synonyms

• PKCTheta^-
• PKCTheta^Delta

Description

The floxed region encompassing about 10 kb of sequence, including a neo cassette and exons 3 and 4, was excised via cre mediated recombination in the germline. The deletion eliminated sequence encoding amino acids 10 through 87 and resulted in a frameshift mutation after codon 9. Western blot analysis indicated an absence of protein in thymocytes and CD3+ T cells. Sequence and splice sites corresponding to the testis-expressed isoform were left intact.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations