Allele/Variant

Gucy2ctm1Gar

Species
Mus musculus
Symbol
Gucy2ctm1Gar
Category
allele
Allele of gene
Gucy2c
Transgenic Constructs
None
Synonyms
  • GC-C -
  • Gcc-
Description
Exon 1 was disrupted by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of intestinal mucosal scrapings obtained from homozygous mutant mice. Total intestine mucosal guanylyl cyclase activity was reduced 16-fold relative to wild-type controls, whereas heat-stable enterotoxin (STa)-stimulable guanylyl cyclase activity was absent in mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations