Allele/Variant

Mt1tm1Rch

Species
Mus musculus
Symbol
Mt1tm1Rch
Category
allele
Allele of gene
Mt1
Transgenic Constructs
None
Synonyms
  • MT-I -
  • MT-null
Description
Both metallothionein I and II were disrupted using the same targeting construct. Exon 1 of metallothionein I was disrupted by insertion of a 20 bp synthetic oligomer just downstream from the start codon which caused a frame shift. Northern blot analysis of liver mRNA from homozygotes in which the gene was induced by intraperitoneal injection of copper indicated that transcription did take place in spite of the frame shift. However, translation of the protein product did not occur.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations