Version: 8.0.0
Date: Tue Jan 28 2025
Runx1tm2Spe
MGI:2668479
Allele of Runx1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Runx1tm2Spe

Species
Mus musculus
Symbol
Runx1tm2Spe
Category
allele
Allele of gene
Runx1
Transgenic Constructs
None
Synonyms
  • Cbfa2lz
  • Runx1-LacZ KI
Description
A 10kb segment including exons 7 and 8 (but not the splice acceptor site of exon 7) was replaced with lacZ coding sequence followed by a PGK-neomycin resistance gene. A fusion protein is produced which contains the N-terminal 242 amino acids of Runx1, including its nuclear localization sequences, combined with beta-galactosidase sequences. The fusion protein lacks Runx1 function.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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