Allele/Variant

Wdr1rede

Species
Mus musculus
Symbol
Wdr1rede
Category
allele
Allele of gene
Wdr1
Transgenic Constructs
None
Synonyms
  • redem01Jus
  • redears
Description
This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion is a T-to-A transversion mutation in the second dinucleotide of the intron 9 splice donor. Splicing of the normal trancript is reduced to 20-30% and an aberrant transcript using a cryptic site is expressed. While a small amount of wild-type protein is expressed, the aberrent transcript is predicted to express a mutant protein that lacks 2 amino acids from the sixth WD40 repeat. This mutation is hypomorphic.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations