Version: 8.0.0
Date: Tue Jan 28 2025
Stat3tm1Desi
MGI:2673309
Allele of Stat3
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Stat3tm1Desi

Species
Mus musculus
Symbol
Stat3tm1Desi
Category
allele
Allele of gene
Stat3
Transgenic Constructs
None
Synonyms
  • Stat3Beta-
Description
Exon 23 was replaced with modified sequence in which nucleotide susbtitutions within 3 polypyrimidine tracts and an AG dinucleotide were made in order to disrupt an internal splice acceptor site specific to the beta isoform. Transcript encoding the beta isoform was undetected by RT-PCR analysis of homozygous mutant hepatic mRNA, while wild-type levels of transcript encoding the alpha isoform were observed. Analysis of MEFs reiterated these findings at the protein level.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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