Version: 8.0.0
Date: Tue Jan 28 2025
Egfrtm2(EGFR)Wag
MGI:2673586
Allele of Egfr
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Egfrtm2(EGFR)Wag

Species
Mus musculus
Symbol
Egfrtm2(EGFR)Wag
Category
allele
Allele of gene
Egfr
Transgenic Constructs
Synonyms
  • hEGFRKI
Description
Floxed human cDNA encoding EGFR was inserted at the endogenous locus via homologous recombination. A RSV-neo cassette was inserted downstream of the human sequence. While endogenous levels of the human transcript were detected in brain tissue by RNAse protection, hypomorphic expression was observed in bone and epithelial tissue, putatively due to an effect of the downstream neo cassette.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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