Allele/Variant

Cacna1ctm2Hfm

Species
Mus musculus
Symbol
Cacna1ctm2Hfm
Category
allele
Allele of gene
Cacna1c
Transgenic Constructs
None
Synonyms
  • L1
  • Line B
Description
Exons 14 and 15, which together encode the transmembrane IIS5 segment and the pore in repeat II, were flanked by loxP sites and subsequently excised in vitro cre-mediated recombination prior to germline transmission. Though RT-PCR revealed aberrant transcript in which exon 13 had spliced to a point within intron 16, no protein was detected in the hearts of homozygous mutant embryos by Western blot analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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