Allele/Variant

Pgrtm2Omc

Species
Mus musculus
Symbol
Pgrtm2Omc
Category
allele
Allele of gene
Pgr
Transgenic Constructs
None
Synonyms
  • PRBKO-
Description
To eliminate the translation of isoform B, the start codon of isoform B was mutated to encode leucine (ATG to CTG). A single loxP site remained in an intron after a floxed selection cassette was excised via cre mediated recombination. While isoform B was undetected by Western blot analysis of homozygous mutant uterine extracts, the presence of isoform A was confirmed.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal branching of the mammary ductal tree
MGI
abnormal lactation
MGI
abnormal mammary gland alveolus morphology
MGI
abnormal mammary gland epithelium morphology
MGI
abnormal mammary gland growth during pregnancy
MGI
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Disease Associations