Dnase2b^tm1Osa

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Species

Mus musculus

Symbol

Dnase2b^tm1Osa

Category

allele

Allele of gene

Dnase2b

Transgenic Constructs

None

Synonyms

• DLAD^-

Description

Exons 3 and 4 were replaced with a neomycin selection cassette inserted by homologous recombination. Included in the deleted region were codons for 2 conserved histidine residues that are putative enzymatic active sites. Truncated transcript lacking the targeted sequence, and consequently containing a frameshift mutation, was detected in mutant mice by both Northern and RT-PCR analyses. Absence of DNAse activity under acidic conditions indicated that stable and functional protein was not produced by the mutant transcript.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations