Cdk2^tm1Sgo

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Species

Mus musculus

Symbol

Cdk2^tm1Sgo

Category

allele

Allele of gene

Cdk2

Transgenic Constructs

None

Synonyms

• Cdk2^-

Description

A neomycin resistance gene flanked by loxP sites was inserted into intron 3 while a third loxP site was inserted into intron 1, generating Cdk2^tm2Sgo. The present allele resulted from Cre recombinase-mediated excision of exons 2 and 3 (and the selection cassette), leading to a predicted reading frame shift. Gene modification was confirmed by RT-PCR and sequencing of the resulting PCR product.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations