Version: 8.0.0
Date: Tue Jan 28 2025
Gja1tm5(cre/ERT)Kwi
MGI:2676327
Allele of Gja1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Gja1tm5(cre/ERT)Kwi

Species
Mus musculus
Symbol
Gja1tm5(cre/ERT)Kwi
Category
allele
Allele of gene
Gja1
Transgenic Constructs
Synonyms
  • Cx43Cre-ER(T)
  • Gja1tm2(cre/ESR1)Kwi
Description
The coding region was replaced with a construct encoding a tamoxifen dependent cre recombinase. The cre recombinase coding region was joined to sequence encoding the ligand binding domain of the human estrogen receptor with a glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. Tamoxifen treatment permits the translocation of the cre hybrid protein to the nucleus.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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