Nkx2-1^tm1Jaw

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Species

Mus musculus

Symbol

Nkx2-1^tm1Jaw

Category

allele

Allele of gene

Nkx2-1

Transgenic Constructs

None

Synonyms

• Titf1^PM

Description

Sequence encoding S80, a phosphorylation mutant allele of the orthologous rat gene in which 7 serine codons are replaced with alanine codons, was inserted in place of a fragment extending from the start codon (bp 7957) to the end of the homeobox (bp 9480). A polyadenylation signal and neo cassette were included immediately downstream of S80. Southern blot analysis confirmed the integration of the mutation that putatively produces a protein lacking residues required for phosphorylation.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations