Hba-a1^tm1Led

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Species

Mus musculus

Symbol

Hba-a1^tm1Led

Category

allele

Allele of gene

Hba-a1

Transgenic Constructs

None

Synonyms

• alpha1-

Description

A neomycin selection cassette replaced a small 295 bp fragment in the second exon of the gene. Northern blot analysis on RNA derived from homozygous embryos demonstrated that a reduced amount of alpha-globin transcript was present in comparison to wild type. The authors propose that the remaining mRNA arose from the adjacent Hba-a2 gene.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations