Allele/Variant

Sftpdtm2Haw

Species
Mus musculus
Symbol
Sftpdtm2Haw
Category
allele
Allele of gene
Sftpd
Transgenic Constructs
None
Synonyms
  • SP-AD(-)
Description
Using ES cells in which a correctly targeted modification of the Sftpa gene had already been created, exon 2 along with the translation start site, was replaced with a PGK-neomycin cassette. Northern blot analysis demonstrated the absence of any Sftpa mRNA in any doubly homozygous mice as well as the absence of full length Sftpd mRNA. A small amount of truncated mRNA for Sftpd lacking the translation start site was seen. Western blot analysis confirmed that no protein products were produced.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations