Allele/Variant

Top1tm1Unc

Species
Mus musculus
Symbol
Top1tm1Unc
Category
allele
Allele of gene
Top1
Transgenic Constructs
None
Synonyms
  • Top-1 -
Description
A neomycin selection cassette replaced a genomic fragment containing exon 15. Western blot analysis demonstrated that a 45% reduction of encoded protein levels was present in cells derived from heterozygous mice. Cytological analysis of early homozygous mutant embryos demonstrated that no detectable protein was produced from this allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Phenotype
Annotation details
Source
References
embryonic lethality before implantation, complete penetrance
MGI
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Disease Associations