Allele/Variant

Crebbptm1Reck

Species
Mus musculus
Symbol
Crebbptm1Reck
Category
allele
Allele of gene
Crebbp
Transgenic Constructs
None
Synonyms
  • cbpAS
Description
Acetyltransferase (AT) activity was ablated via the incorporation of engineered point mutations at the endogenous locus. The mutations substitute alanine and serine for tryptophan and tyrosine (WY(1503-1504)AS). A single loxP site remained in the intron preceding the missense mutations after the excision of floxed neo cassette used for selection. Western blot analysis indicated mutant protein was expressed at wild-type levels.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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