Zfhx3^Sci

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Species

Mus musculus

Symbol

Zfhx3^Sci

Category

allele

Allele of gene

Zfhx3

Transgenic Constructs

None

Synonyms

• PLAY 8

Description

This phenotypic mutation was identified in an ENU mutagenesis screen at the MRC Mammalian Genetics Unit, Harwell, UK. A point mutation in Zfhx3 was identified in exon 9, resulting in a G to T transversion at position 6620 and a substitution of a phenylalanine for a valine at residue 1963 (V1963F) in a highly conserved region just upstream of the 17th zinc-finger motif. This appears to be a gain of function allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations