Trp53^tm1Xu

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Species

Mus musculus

Symbol

Trp53^tm1Xu

Category

allele

Allele of gene

Trp53

Transgenic Constructs

None

Synonyms

• p53^S18A

Description

Site directed mutagenesis within exon 2 generated a missense mutation (AG>GC) at codon 18 resulting in the substitution of serine with alanine (p.S18A). Serine 18 corresponds with human serine 15 of TP53 and this mutation prevents phosphorylation of the residue in the encoded peptide. A single loxP site remained in intron 3 after the inserted loxP site flanked neomycin resistance gene cassette was excised via Cre-mediated recombination.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations