Mapkapk5^tm1Mgl

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Species

Mus musculus

Symbol

Mapkapk5^tm1Mgl

Category

allele

Allele of gene

Mapkapk5

Transgenic Constructs

None

Synonyms

• deltaex6
• MK5-

Description

Exon 6 was replaced with a neo cassette. The targeted exon encoded amino acids 131 through 161 which make up portions of the kinase catalytic core subdomains VIa and VIb. Northern blot and RT-PCR analyses identified mutant transcript approximately 100 bp shorter than normal transcript. Sequence analysis showed the mutant transcript to contain neither exon 6 nor the neo cassette. Low levels of truncated protein were detected by Western blot analysis, but this protein was reported to lack catalytic activity.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations