Allele/Variant

Prkntm1Shn

Species
Mus musculus
Symbol
Prkntm1Shn
Category
allele
Allele of gene
Prkn
Transgenic Constructs
None
Synonyms
  • Park2tm1Shn
  • parkin -
Description
Exon 3 was replaced in-frame by the coding sequence for EGFP followed by a PGK-neomycin cassette. RT-PCR analysis indicated that exon 2 spliced to exon 4 in transcripts thus skipping exon 3 entirely. This results in a frame shift and a premature stop codon in exon 5. Western blot analysis using antibody specific to C-terminal sequences indicated the absence of gene product.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations