Allele/Variant

Pdgfrbtm9Sor

Species
Mus musculus
Symbol
Pdgfrbtm9Sor
Category
allele
Allele of gene
Pdgfrb
Transgenic Constructs
None
Synonyms
  • F7
  • PdgfrbF7
Description
7 point mutations were engineered and incorporated at the endogenous locus via homologous recombination of a targeting vector. Each mutation elicited a missense mutation, ablating tyrosine residues involved in Src, Grb2, PI3-K, RasGAP, SHP-2, and PLC-gamma signal transduction. Tyrosines at codons 578, 715, 739, 750, 770, and 1008 are substituted with phenylalanine, and a tyrosine at 1020 is substituted with isoleucine. A single FRT and loxP sites were left in introns 12 and 16, respectively.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations