Pdgfrb^tm9Sor

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Species

Mus musculus

Symbol

Pdgfrb^tm9Sor

Category

allele

Allele of gene

Pdgfrb

Transgenic Constructs

None

Synonyms

• F7
• Pdgfrb^F7

Description

7 point mutations were engineered and incorporated at the endogenous locus via homologous recombination of a targeting vector. Each mutation elicited a missense mutation, ablating tyrosine residues involved in Src, Grb2, PI3-K, RasGAP, SHP-2, and PLC-gamma signal transduction. Tyrosines at codons 578, 715, 739, 750, 770, and 1008 are substituted with phenylalanine, and a tyrosine at 1020 is substituted with isoleucine. A single FRT and loxP sites were left in introns 12 and 16, respectively.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations