Allele/Variant

Pde7aGt(Betageo-puro)1Yang

Species
Mus musculus
Symbol
Pde7aGt(Betageo-puro)1Yang
Category
allele
Allele of gene
Pde7a
Transgenic Constructs
None
Synonyms
  • PDE7A-
Description
A gene trap vector containing beta-geo, puro, and flanking long terminal repeats inserted into an intron of the endogenous locus, corresponding with human intron 5. RT-PCR analysis of splenic mRNA indicated an absence of normal transcript in homozygous mutant mice. Though mutant transcript species comprising sequence either 5' or 3' to the gene trap insertion were detected, transcript containing an undisrupted catalytic domain was not detected in homozygous mutant mice. Endogenous enzymatic activity was not detected in homozygous lymph node lysates.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal humoral immune responseMGI
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Disease Associations

No data available