Med1^tm1Mpk

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Species

Mus musculus

Symbol

Med1^tm1Mpk

Category

allele

Allele of gene

Med1

Transgenic Constructs

None

Synonyms

• TRAP220^con
• TRAP220^hyp

Description

A floxed neomycin resistance gene was placed in intron 2 while an additional loxP site was inserted in exon 1. The resulting construct was a hypomorph expressing 80% less mRNA than normal and with a comparable reduction in protein product. Transient transfection of properly targeted ES cells with a cre expression vector to remove neomycin but leaving exon 1 and 2 in place but flanked by loxP sites also resulted in a hypomorph with an identical phenotypic effect.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations