Atp1a2^tm3Ling

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Species

Mus musculus

Symbol

Atp1a2^tm3Ling

Category

allele

Allele of gene

Atp1a2

Transgenic Constructs

None

Synonyms

• alpha2^R

Description

Two missense mutations (L111R and N122D) were engineered into exon 4. A floxed neo cassette included in the targeting vector was excised from intron 3 prior to germline transmission. The mutations, which manifest in the first extracellular domain of the alpha 2 isoform, impair cardiac glycoside affinity. Western blot analysis of mutant mice indicated that the mutations did not affect either the level protein expression or the distribution of the alpha 1 and alpha 3 isoforms.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations