Tnfsf13^tm1Ash

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Species

Mus musculus

Symbol

Tnfsf13^tm1Ash

Category

allele

Allele of gene

Tnfsf13

Transgenic Constructs

None

Synonyms

• APRIL^-

Description

A 2.5 kb genomic fragment, encompassing a portion of exon 1 and all of exons 2 through 6, was replaced with a neo cassette. The deletion was designed to eliminate both the secreted and transmembrane porteins produced by the endogenous locus. Tnfsf13 protein was undetected by FACS analysis of homozygous mutant splenocytes. Real-time RT-PCR indicated that the levels of Tnfsf12 and Senp3 transcript, produced by loci in close proximity to Tnfsf13, were not affected by the targeting event.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations