Dph1^tm2Bhr

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Species

Mus musculus

Symbol

Dph1^tm2Bhr

Category

allele

Allele of gene

Dph1

Transgenic Constructs

None

Synonyms

• Ovca1-2^-

Description

Exons 7 to 12 as well as part of exon 13 were replaced with a floxed neomycin resistance gene. In the process, exon 1 of Ovca2 which is located between exons 12 and 13 was also deleted. Targeting took place in PC3 ES cells homozygous for Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. Cre mediated excision subsequently removed the neomycin cassette upon transmission from male chimeric mice. RT-PCR indicated that no full length transcripts were produced but transcripts were produced from exons 1-6.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations