Itpkb^T-less

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Species

Mus musculus

Symbol

Itpkb^T-less

Category

allele

Allele of gene

Itpkb

Transgenic Constructs

None

Synonyms

• Itpkb^-
• Ms T less

Description

A T to A transversion at position 596 of the transcript created a premature stop codon in place of cysteine 199. Northern blot revealed abundant transcript in mutant DP thymocytes, putatively encoding an N-terminally truncated protein lacking the targeting, regulating, and catalytic domains. Western blot detected no full-length protein. Kinase activity was about 50% less than that in wild-type thymocytes.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations