Stat3^tm2Vpo

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Species

Mus musculus

Symbol

Stat3^tm2Vpo

Category

allele

Allele of gene

Stat3

Transgenic Constructs

None

Synonyms

• Stat3^deltaalpha

Description

To generate an allele in which the expression of the alpha isoform is completely ablated while the expression of the beta isoform is maintained, cDNA encoding the C-terminal of the beta isoform, as well as a polyA-neo cassette, was inserted into exon 20. RT-PCR and Western blot analyses of homozygous mutant liver confirmed the absence of the alpha isoform. Comparisions with the level of alpha isoform transcript and protein in wild-type mice indicated that while the level of beta isoform transcript is equivalent, the level of beta isoform protein is reduced.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations