Allele/Variant

Ppp3r1tm1Grc

Species
Mus musculus
Symbol
Ppp3r1tm1Grc
Category
allele
Allele of gene
Ppp3r1
Transgenic Constructs
None
Synonyms
  • CnB*
Description
Sequence encoding an FRB* peptide tag was inserted into exon 5, immediately following the last codon of the coding sequence. This allele produces a protein with a C-terminal FRB* peptide tag that prevents interaction with PPP3CA, thereby eliminating calcium-dependent activation of PPP3CA catalytic activity. An assay indicated the abrogation of caclcineurin phosphatase activity.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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