Allele/Variant

Tg(Dll1-Tbx18)20Akis

Species
Mus musculus
Symbol
Tg(Dll1-Tbx18)20Akis
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • msd::Tbx18
Description
The entire open reading frame of mouse Tbx18 was fused to a mesodermal specific promoter containing a 1495 bp mesodermal element from the 5' untranslated region of the Dll1 gene fused to the Dll1 minimal promoter. Two lines were generated, Tg(Dll1-Tbx18)2Akis and Tg(Dll1-Tbx18)20Akis, with the latter showing a more severe homozygous phenotype. The mesodermal specific promoter was first described in J:63760
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal dorsal-ventral polarity of the somitesMGI
abnormal skeleton morphology
MGI
abnormal spinal nerve morphologyMGI
abnormal thoracic cage shapeMGI
abnormal vertebrae morphologyMGI
abnormal vertebral pedicle morphologyMGI
absent proximal ribMGI
decreased embryo sizeMGI
lordosisMGI
small thoracic cageMGI
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Disease Associations

No data available