Map3k4^tm1Flv

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Species

Mus musculus

Symbol

Map3k4^tm1Flv

Category

allele

Allele of gene

Map3k4

Transgenic Constructs

None

Synonyms

• MEKK4-

Description

A loxP site was inserted 5' to exon 3 and a floxed neomycin resistance cassette was placed 3' to the exon. Chimeric male mice were bred to female mice carrying Tg(Tek-cre)12Flv to delete exon 3 and the neomycin resistance gene. This removes the entire GADD45-binding domain and causes a frame shift and premature termination. Absence of protein was confirmed by Western blot analysis.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations