Version: 8.0.0
Date: Tue Jan 28 2025
Fmn1tm1Zllr
MGI:3046836
Allele of Fmn1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Fmn1tm1Zllr

Species
Mus musculus
Symbol
Fmn1tm1Zllr
Category
allele
Allele of gene
Fmn1
Transgenic Constructs
None
Synonyms
  • Fmndelta10
Description
Exon 10 was completely replaced with a PGK promoter and neomycin resistance gene cassette and a loxP site was inserted further downstream in intron 10. A correctly targeted ES cell line was further modified by the insertion of a loxP site flanked PGK promoter and hygromycin resistance gene cassette and an En-2 splice acceptor-IRES-LacZ expression cassette into exon 24. Removal of exon 10 causes a frame shift mutation, which disrupts the highly conserved formin homology domain SH2 and results in a protein product that includes out-of-frame translation after exon 9.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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