Allele/Variant

Dapk1tm1Yuk

Species
Mus musculus
Symbol
Dapk1tm1Yuk
Category
allele
Allele of gene
Dapk1
Transgenic Constructs
None
Synonyms
  • DAPK
Description
Insertion of a neomycin resistance gene deleted part of the exon encoding amino acids 22-95 in the catalytic kinase domain. The replaced region encodes a conserved lysine residue that is critical for the kinase activity of the gene. Western blot analysis demonstrated the existence of the mutant protein with a slightly smaller size that wild-type. RT-PCR analysis of kidneys identified the alternative transcript.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations