Allele/Variant

Tg(APOA2)3Rub

Species
Mus musculus
Symbol
Tg(APOA2)3Rub
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • AII/Fu-9
  • apoA-II/A-IKO
Description
5 kb of promoter sequence to the human APOA-I gene were fused to human APOA-II coding sequence. 10 copies of the transgene intergrated into the genome of this founder strain. In these mice, human APOA2 mRNA is found only in the liver. Transgenic mice express a dimeric form of human apolipoprotein A-II. Levels of murine HDL, APOA1, and APOA2 in transgenic mice were comparable to those found in normal wildtype siblings.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations