Mbnl1^tm1Sws

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Species

Mus musculus

Symbol

Mbnl1^tm1Sws

Category

allele

Allele of gene

Mbnl1

Transgenic Constructs

None

Synonyms

• Mbnl1^deltaE3

Description

A loxP-flanked neomycin selection cassette replaced exon 3 and flanking sequence. The neomycin cassette was removed by transient Cre expression in ES cells prior to the production of chimeric mice. RT-PCR analysis demonstrated that no transcripts with sequences from exon 3 were present, but other splice isoforms expressed from this gene were detectable. Immunoblot analysis further confirmed the absence of protein isoforms containing sequences encoded by exon 3.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations