Tg(H2-K-Fos)1Wag

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Species

Mus musculus

Symbol

Tg(H2-K-Fos)1Wag

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

• H2-c-fos
• Tg(H2-c-fos)

Description

The transgene comprises a 4.1 kb genomic DNA fragment including the translation initiation codon, all exons and introns, and the polyadenylation signal of the mouse FBJ osteosarcoma [proto-] oncogene joined to a 2 kb fragment containing the promoter and the first nine transcribed base pairs of the mouse H2-K^b gene. All five transgenic lines expressed transgenic mRNA in spleen, thymus, lung and salivary gland, most at high levels; 4/5, at low to moderate levels, in liver and muscle; 3/5 at low levels in heart, gonads and kidney; one, at a low level, in pancreas; and none in brain or bone marrow.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations