Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Ab1TL)1Gru
MGI:3054941Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Ab1TL)1Gru

Species
Mus musculus
Symbol
Tg(Ab1TL)1Gru
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
This beta chain transgene expresses a truncated class II A beta molecules that lack the 13 membrane distal residues. Transgene expression was detected on B cells and stimulated macrophages, with the expression on B cells being about a log unit higher than endogenous expression. Immunoprecipitation of B cell lysates confirmed a truncated I-Abeta chain was being expressed.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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