Version: 8.0.0
Date: Tue Jan 28 2025
Trp53tm4Tyj
MGI:3056071
Allele of Trp53
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Trp53tm4Tyj

Species
Mus musculus
Symbol
Trp53tm4Tyj
Category
allele
Allele of gene
Trp53
Transgenic Constructs
None
Synonyms
  • S23A
Description
Serine codon 23 (TCA) in exon 2 was changed to alanine (GCA) (p.S23A). Transient cre recombinase expression excised a loxP site flanked puromycin resistance gene cassette that was inserted into intron1. RT-PCR of mutant MEFs confirmed correct targeting. The mutation prevents the phosphorylation of the residue in the encoded peptide.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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