Version: 8.0.0
Date: Tue Jan 28 2025
Tg(FCGR2A)11Mkz
MGI:3056729Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(FCGR2A)11Mkz

Species
Mus musculus
Symbol
Tg(FCGR2A)11Mkz
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • FcgammaRIIATGN
  • huFCGR2AR131
Description
The transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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