Tg(HBA-HBBs)41Paz

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Species

Mus musculus

Symbol

Tg(HBA-HBBs)41Paz

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

• miniLCRalpha1^Ggamma^Agammadeltabeta^S
• Tg(Hu-miniLCRalpha1^Ggamma^Agammadeltabeta^S)

Description

The transgene contains sequences encoding the human proteins HBA1 (hemoglobin, alpha 1), HBG2 (hemoglobin, gamma G, fetal component), HBG1 (hemoglobin, gamma A, fetal component), HBD (hemoglobin, delta), and HBB ^S (hemoglobin, beta, sickle allele), and the locus control region (LCR). The HBB^S allele contains an A to T transversion mutation in the sixth codon of HBB which causes an amino acid change from Glu to Val. The transgene promoter is multiple: from alpha and beta globin human loci. Transgenic mice express human alpha hemoglobin, gamma hemoglobin, and sickle cell hemoglobin.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations