Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(GFAP-APOE_i3)37Hol
- Species
- Mus musculus
- Symbol
- Tg(GFAP-APOE_i3)37Hol
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- GFAP-apoE3 line 37
- Tg(GFAP-APOE*3)37Hol
- Description
- The transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None